Gemifloxacin use in the treatment of acute bacterial exacerbation of chronic bronchitis

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Gemifloxacin use in the treatment of acute bacterial exacerbation of chronic bronchitis

The newest generation of fluoroquinolones have proven efficacy against bacterial organisms associated with acute exacerbation of chronic bronchitis (AECB). Gemifloxacin, as one of the quinolones in this class, exhibits many of the pharmacokinetic and pharmacodynamic characteristics of the class with a few notable differences. Against Streptococccus pneumoniae it has a lower minimal inhibitory c...

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Gemifloxacin for the Treatment of Acute Bacterial Exacerbation of Chronic Bronchitis and Community-Acquired Pneumonia

Chronic Bronchitis Chronic bronchitis is a major health problem associated with significant morbidity and mortality and affects more than 14 million individuals in the U.S.2 Patients are predisposed to frequent exacerbations, characterized by increased cough, increased sputum volume, purulence, and respiratory distress. On average, one to four exacerbations occur each year in these patients and...

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Treatment of acute bacterial exacerbations of chronic bronchitis.

BACKGROUND Controversies persist regarding the optimal management of patients with acute exacerbations of chronic bronchitis (AECB). OBJECTIVE To evaluate the available evidence on relevant issues, namely the need for administering antimicrobials in patients with AECB, the identification of the subgroup of patients with AECB needing antibiotics, the antimicrobial regimen of choice and its opt...

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Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis

Exacerbations of chronic bronchitis (AECB) are a major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and their impact on public health is increasing. The new fluoroquinolones have an excellent spectrum providing cover for the most important respiratory pathogens, including atypical and "typical" pathogens. Not surprisingly, different guidelines ...

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ژورنال

عنوان ژورنال: International Journal of Chronic Obstructive Pulmonary Disease

سال: 2009

ISSN: 1178-2005

DOI: 10.2147/copd.s3903